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BIOLOGY (1316 journals)            First | 6 7 8 9 10 11 12 13 | Last

Membrane Protein Transport     Full-text available via subscription   (Followers: 3)
Memoirs of the Association of Australasian Palaeontologists     Full-text available via subscription   (Followers: 2)
Metabolic Engineering     Hybrid Journal   (Followers: 4)
Metabolites     Open Access   (Followers: 1)
Metabolomics     Hybrid Journal   (Followers: 5)
Metallomics     Full-text available via subscription  
Methods     Hybrid Journal   (Followers: 11)
Methods in Cell Biology     Full-text available via subscription   (Followers: 7)
Methods in Cell Science     Hybrid Journal   (Followers: 3)
Methods in Ecology and Evolution     Partially Free   (Followers: 13)
Micologia Aplicada Internacional     Open Access  
Microarrays     Open Access  
Micron     Hybrid Journal  
Mitochondrial DNA     Hybrid Journal   (Followers: 3)
Mitochondrion     Hybrid Journal   (Followers: 3)
Modelling and Simulation in Engineering     Open Access   (Followers: 4)
Modelling and Simulation in Materials Science and Engineering     Hybrid Journal   (Followers: 7)
Molecular & Cellular Proteomics     Full-text available via subscription   (Followers: 7)
Molecular & Cellular Toxicology     Hybrid Journal   (Followers: 2)
Molecular and Biochemical Parasitology     Hybrid Journal   (Followers: 2)
Molecular and Cellular Biochemistry     Hybrid Journal   (Followers: 4)
Molecular and Cellular Biology     Full-text available via subscription   (Followers: 16)
Molecular Based Mathematical Biology     Open Access  
Molecular Biology     Hybrid Journal   (Followers: 10)
Molecular Biology and Evolution     Hybrid Journal   (Followers: 125)
Molecular Biology International     Open Access   (Followers: 3)
Molecular Biology of the Cell     Partially Free   (Followers: 15)
Molecular Biology Reports     Hybrid Journal   (Followers: 4)
Molecular Brain     Open Access   (Followers: 2)
Molecular Breeding     Hybrid Journal   (Followers: 6)
Molecular Cell     Full-text available via subscription   (Followers: 32)
Molecular Ecology     Hybrid Journal   (Followers: 14)
Molecular Ecology Resources     Hybrid Journal   (Followers: 8)
Molecular Genetics and Metabolism     Hybrid Journal   (Followers: 6)
Molecular Immunology     Hybrid Journal   (Followers: 13)
Molecular Membrane Biology     Hybrid Journal   (Followers: 1)
Molecular Neurobiology     Hybrid Journal   (Followers: 3)
Molecular Pain     Open Access  
Molecular Plant-Microbe Interactions     Partially Free   (Followers: 5)
Molecular Reproduction & Development     Hybrid Journal   (Followers: 6)
Molecular Therapy - Nucleic Acids     Open Access  
Molecules and Cells     Hybrid Journal   (Followers: 1)
Momona Ethiopian Journal of Science     Open Access   (Followers: 2)
Monoclonal Antibodies in Immunodiagnosis and Immunotherapy     Hybrid Journal  
Monographs of the Western North American Naturalist     Full-text available via subscription   (Followers: 1)
Moscow University Physics Bulletin     Hybrid Journal  
Movement Ecology     Open Access   (Followers: 4)
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis     Hybrid Journal   (Followers: 2)
Mutation Research/Genetic Toxicology and Environmental Mutagenesis     Hybrid Journal   (Followers: 8)
Mutation Research/Reviews in Mutation Research     Hybrid Journal   (Followers: 4)
Mycological Progress     Hybrid Journal   (Followers: 1)
Mycopathologia     Hybrid Journal   (Followers: 1)
Mycorrhiza     Hybrid Journal   (Followers: 5)
Mycoscience     Hybrid Journal   (Followers: 1)
Mycotoxin Research     Hybrid Journal   (Followers: 4)
NAMMCO Scientific Publications     Open Access  
Nano Reviews     Open Access   (Followers: 15)
Nano Today     Hybrid Journal   (Followers: 10)
Nanoscale Research Letters     Open Access   (Followers: 4)
Natural Hazards     Hybrid Journal   (Followers: 176)
Natural History     Full-text available via subscription   (Followers: 4)
Natural Product Research: Formerly Natural Product Letters     Hybrid Journal   (Followers: 1)
Natural Science     Open Access   (Followers: 9)
Nature     Full-text available via subscription   (Followers: 2090)
Nature Cell Biology     Full-text available via subscription   (Followers: 196)
Nature China     Full-text available via subscription   (Followers: 5)
Nature Digest     Full-text available via subscription   (Followers: 4)
Nature Protocols     Full-text available via subscription   (Followers: 39)
Nature Reviews Molecular Cell Biology     Full-text available via subscription   (Followers: 174)
Nature Structural & Molecular Biology     Full-text available via subscription   (Followers: 154)
Naturwissenschaften     Hybrid Journal   (Followers: 4)
Nematology     Full-text available via subscription   (Followers: 2)
Nematropica     Open Access  
NeoBiota     Open Access   (Followers: 2)
Neotropical Ichthyology     Open Access  
Nepal Journal of Science and Technology     Open Access  
Neurobiology of Aging     Hybrid Journal   (Followers: 3)
Neurobiology of Disease     Hybrid Journal   (Followers: 3)
NeuroImmune Biology     Full-text available via subscription  
Neuroinformatics     Hybrid Journal   (Followers: 2)
Neuropeptides     Hybrid Journal   (Followers: 2)
Neuropsychobiology     Full-text available via subscription   (Followers: 3)
New Biotechnology     Hybrid Journal   (Followers: 4)
New Journal of Physics     Open Access   (Followers: 7)
New Phytologist     Hybrid Journal   (Followers: 10)
New Zealand Journal of Marine and Freshwater Research     Hybrid Journal   (Followers: 4)
Nigerian Journal of Basic and Applied Sciences     Open Access   (Followers: 2)
Nigerian Journal of Parasitology     Full-text available via subscription   (Followers: 1)
Nigerian Journal of Physiological Sciences     Open Access  
NJAS - Wageningen Journal of Life Sciences     Full-text available via subscription   (Followers: 1)
NMR in Biomedicine     Hybrid Journal   (Followers: 1)
Non-Genetic Inheritance     Open Access   (Followers: 1)
Nonlinear Biomedical Physics     Open Access  
Northern Territory Naturalist     Full-text available via subscription  
Northwest Science     Full-text available via subscription   (Followers: 1)
Nova Hedwigia     Full-text available via subscription   (Followers: 2)
Nuclear Medicine and Biology     Hybrid Journal   (Followers: 1)
Nucleic Acid Therapeutics     Hybrid Journal  
Nucleic Acids Research     Open Access   (Followers: 24)
Nucleic Acids Symposium Series     Hybrid Journal  

  First | 6 7 8 9 10 11 12 13 | Last

Journal Cover Biochemistry and Cell Biology
   [10 followers]  Follow    
   Full-text available via subscription Subscription journal
     ISSN (Print) 0829-8211 - ISSN (Online) 1208-6002
     Published by NRC Research Press Homepage  [18 journals]   [SJR: 1.488]   [H-I: 65]
  • Functional expression of the Acanthamoeba castellanii alternative oxidase
           in Escherichia coli; regulation of the activity and evidence for Acaox
           gene function
    • Authors: Nina Antos-Krzeminska; Wieslawa Jarmuszkiewicz
      Abstract: Biochemistry and Cell Biology, Volume 92, Issue 3, Page 235-241, June 2014. To evidence Acanthamoeba castellanii alternative oxidase (AcAOX) gene product function, we studied alterations in the levels of mRNA and protein and AcAOX activity during growth in amoeba batch culture. Moreover, heterologous expression of AcAOX in AOX-deficient Escherichia coli confirmed by the protein immunodetection and functional studies was performed. Despite the presence of native bo and bd quinol oxidases in E. coli membrane, from which the latter is known to be cyanide-resistant, functional expression of AcAOX in E. coli conferred cyanide-resistant benzohydroxamate-sensitive respiration on the bacteria. Moreover, AcAOX activity in transformed bacteria was stimulated by GMP and inhibited by ATP, indicating that AcAOX is regulated by mutual exclusion of purine nucleotides, which was previously demonstrated in the mitochondria of A. castellanii.
      PubDate: Mon, 05 May 2014 07:00:00 GMT
  • Myostatin inhibits proliferation and insulin-stimulated glucose uptake in
           mouse liver cells
    • Authors: Rani Watts; Mostafa Ghozlan, Curtis C. Hughey, Virginia L. Johnsen, Jane Shearer, Dustin S. Hittel
      Abstract: Biochemistry and Cell Biology, Volume 92, Issue 3, Page 226-234, June 2014. Although myostatin functions primarily as a negative regulator of skeletal muscle growth and development, accumulating biological and epidemiological evidence indicates an important contributing role in liver disease. In this study, we demonstrate that myostatin suppresses the proliferation of mouse Hepa-1c1c7 murine-derived liver cells (50%; p < 0.001) in part by reducing the expression of the cyclins and cyclin-dependent kinases that elicit G1-S phase transition of the cell cycle (p < 0.001). Furthermore, real-time PCR-based quantification of the long noncoding RNA metastasis associated lung adenocarcinoma transcript 1 (Malat1), recently identified as a myostatin-responsive transcript in skeletal muscle, revealed a significant downregulation (25% and 50%, respectively; p < 0.05) in the livers of myostatin-treated mice and liver cells. The importance of Malat1 in liver cell proliferation was confirmed via arrested liver cell proliferation (p < 0.05) in response to partial Malat1 siRNA-mediated knockdown. Myostatin also significantly blunted insulin-stimulated glucose uptake and Akt phosphorylation in liver cells while increasing the phosphorylation of myristoylated alanine-rich C-kinase substrate (MARCKS), a protein that is essential for cancer cell proliferation and insulin-stimulated glucose transport. Together, these findings reveal a plausible mechanism by which circulating myostatin contributes to the diminished regenerative capacity of the liver and diseases characterized by liver insulin resistance.
      PubDate: Thu, 24 Apr 2014 07:00:00 GMT
  • Interaction of Grb2 SH3 domain with UVRAG in an Alzheimer’s
           disease–like scenario
    • Authors: Kasturi Roy; Oishee Chakrabarti, Debashis Mukhopadhyay
      Abstract: Biochemistry and Cell Biology, Volume 92, Issue 3, Page 219-225, June 2014. Growth factor receptor-bound protein 2 (Grb2) is an adaptor protein which participates in trafficking pathways alongside its role in signaling. Proteins important for actin remodeling and cellular compartmentalization contain SRC Homology 3 (SH3) binding motifs that interact with Grb2. While studying the Grb2–amyloid precursor protein (APP) intracellular domain (AICD) interaction in Alzheimer’s disease cell line models, it was seen that Grb2 colocalized to compartments that mature into autophagosomes. The entrapping of AICD in the Grb2 vesicles and its clearance via autophagosomes was a survival contrivance on the part of the cell. Here, we report that Grb2, when in excess, interacts with ultraviolet radiation resistance-associated gene protein (UVRAG) under excess conditions of AICD–Grb2 or Grb2. The N-terminal SH3 domain of Grb2 specifically interacts with UVRAG, unlike the C-terminal SH3 domain. This interaction helps to understand the role of Grb2 in the autophagic maturation of vesicles.
      PubDate: Thu, 24 Apr 2014 07:00:00 GMT
  • Targeting angiogenic pathway for chemoprevention of experimental colon
           cancer using C-phycocyanin as cyclooxygenase-2 inhibitor
    • Authors: Manpreet Kaur Saini; Sankar Nath Sanyal
      Abstract: Biochemistry and Cell Biology, Volume 92, Issue 3, Page 206-218, June 2014. An angiogenic pathway was studied that involved stromal tissue degradation with matrix metalloproteinases (MMPs), vesicular endothelial growth factor-A (VEGF-A), and hypoxia inducible factor-1α (HIF-1α) mediated growth regulation in a complex interaction with chemokines, such as monocyte chemoattractant protein-1 (MCP-1) and macrophage inflammatory protein-1β (MIP-1β). Gene and protein expression was studied with real-time PCR, Western immunoblot, and immunofluorescence. Morphological and histopathological analysis of tumor was done, as also the activity of MMPs and HIF-1α by gelatin zymography and ELISA. Binding interactions of proteins were studied by molecular docking. Piroxicam, a traditional NSAID and C-phycocyanin, a biliprotein from Spirulina platensis, were utilized in the chemoprevention of DMH-induced rat colon cancer. A significant number of tumors was evident in DMH treated animals, while with piroxicam and C-phycocyanin, the number and size of tumors/lesions were reduced. Colonic tissues showed severe dysplasia, tubular adenoma, and adenocarcinoma from DMH, with invasive features along with signet ring cell carcinoma. No occurrence of carcinoma was detected in either of the drug treatments or in a combination regimen. An elevated VEGF-A, MMP-2, and MMP-9 level was observed, which is required for metastasis and invasion into surrounding tissues. Drugs induced chemoprevention by down-regulating these proteins. Piroxicam docked in VEGF-A binding site of VEGF-A receptors i.e., VEGFR1 and VEGFR2, while phycocyanobilin (a chromophore of C-phycocyanin) docked with VEGFR1 alone. HIF-1α is up-regulated which is associated with increased oxygen demand and angiogenesis. MCP-1 and MIP-1β expression was also found altered in DMH and regulated by the drugs. Anti-angiogenic role of piroxicam and C-phycocyanin is well demonstrated.
      PubDate: Thu, 24 Apr 2014 07:00:00 GMT
  • Cationic lipid nanodisks as an siRNA delivery vehicle
    • Authors: Mistuni Ghosh; Gang Ren, Jens B. Simonsen, Robert O. Ryan
      Abstract: Biochemistry and Cell Biology, Volume 92, Issue 3, Page 200-205, June 2014. The term nanodisk (ND) describes reconstituted high-density lipoprotein particles that contain one or more exogenous bioactive agents. In the present study, ND were assembled from apolipoprotein A-I, the zwitterionic glycerophospholipid 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC), and the synthetic cationic lipid 1,2-dimyristoyl-3-trimethylammonium-propane (DMTAP). ND formulated at a DMPC:DMTAP ratio of 70:30 (by weight) were soluble in aqueous media. The particles generated were polydisperse, with diameters ranging from ∼20 to
      PubDate: Tue, 22 Apr 2014 07:00:00 GMT
  • Role of Nodal–PITX2C signaling pathway in glucose-induced
           cardiomyocyte hypertrophy
    • Authors: Dongmei Su; Sun Jing, Lina Guan, Qian Li, Huiling Zhang, Xiaobo Gao, Xu Ma
      Abstract: Biochemistry and Cell Biology, Volume 92, Issue 3, Page 183-190, June 2014. Pathological cardiac hypertrophy is a major cause of morbidity and mortality in cardiovascular disease. Recent studies have shown that cardiomyocytes, in response to high glucose (HG) stimuli, undergo hypertrophic growth. While much work still needs to be done to elucidate this important mechanism of hypertrophy, previous works have showed that some pathways or genes play important roles in hypertrophy. In this study, we showed that sublethal concentrations of glucose (25 mmol/L) could induce cardiomyocyte hypertrophy with an increase in the cellular surface area and the upregulation of the atrial natriuretic peptide (ANP) gene, a hypertrophic marker. High glucose (HG) treatments resulted in the upregulation of the Nodal gene, which is under-expressed in cardiomyocytes. We also determined that the knockdown of the Nodal gene resisted HG-induced cardiomyocyte hypertrophy. The overexpression of Nodal was able to induce hypertrophy in cardiomyocytes, which was associated with the upregulation of the PITX2C gene. We also showed that increases in the PITX2C expression, in response to Nodal, were mediated by the Smad4 signaling pathway. This study is highly relevant to the understanding of the effects of the Nodal–PITX2C pathway on HG-induced cardiomyocyte hypertrophy, as well as the related molecular mechanisms.
      PubDate: Fri, 28 Mar 2014 07:00:00 GMT
  • Dynamics of WD-repeat containing proteins in SSU processome components
    • Authors: Kouko Wada; Manae Sato, Nanase Araki, Masahiro Kumeta, Yuya Hirai, Kunio Takeyasu, Kazuhiro Furukawa, Tsuneyoshi Horigome
      Abstract: Biochemistry and Cell Biology, Volume 92, Issue 3, Page 191-199, June 2014. Nine WD-repeat containing proteins in human SSU processome components have been found in a HeLa cell nuclear matrix fraction. In these proteins, t-UTP sub-complex components, i.e., CIRH1A, UTP15, and WDR43, were shown to be immobilized in the fibrillar centers of nucleoli in living cells. In this study, the dynamics of the remaining six proteins fused with green fluorescent protein (GFP), i.e., PWP2-GFP, TBL3-GFP, GFP-UTP18, GFP-NOL10, GFP-WDR46, and GFP-WDSOF1, were examined in living cells. The findings were as follows. (i) The majority of UTP-B sub-complex components, i.e., PWP2-GFP, TBL3-GFP, and GFP-UTP18, are localized to the dense fibrillar component and granular component regions in nucleoli; (ii) When rRNA transcription is suppressed, the majority of GFP-fused UTP-B sub-complex components are localized in the cap and body regions of nucleoli. (iii) The mobility of these proteins except for GFP-WDSOF1, and half of GFP-UTP18 and GFP-WDR46, respectively, is very low in living cells. (iv) When rRNA transcription is suppressed, the mobility of these proteins except for GFP-WDSOF1 is accelerated but still slow. These findings and others suggest that these WD-repeat proteins other than GFP-WDSOF1 found in the nuclear matrix fraction bind tightly to some macro-protein complexes and act as a scaffold or a core for the complexes in nucleoli.
      PubDate: Thu, 27 Mar 2014 07:00:00 GMT
  • BMP and activin membrane-bound inhibitor (BAMBI) inhibits the adipogenesis
           of porcine preadipocytes through Wnt/β-catenin signaling pathway
    • Authors: Yin Mai; Zhenyu Zhang, Hao Yang, Peiyue Dong, Guiyan Chu, Gongshe Yang, Shiduo Sun
      Abstract: Biochemistry and Cell Biology, Volume 92, Issue 3, Page 172-182, June 2014. The process of differentiation from preadipocytes to adipocytes contributes to adipose tissue expansion in obesity. Blocking adipogenesis may be conducive to the etiology of obesity-related diseases. BMP and activin membrane-bound inhibitor (BAMBI) is a transmembrane protein, which was identified as a target of β-catenin in colorectal and hepatocellular tumor cells. However, whether BAMBI affects adipogenesis by Wnt/β-catenin signaling remains to be explored. In this study, we distinguish BAMBI as an inhibitor of preadipocytes differentiation. We found that BAMBI was downregulated during preadipocytes differentiation. Knockdown of BAMBI increased adipogenesis and blocked Wnt/β-catenin signaling by repressing β-catenin accumulation. In BAMBI overexpression cells, lipid accumulation was reduced by promoting nuclear translocation of β-catenin. Lithium chloride (LiCl) is an activator of Wnt/β-catenin signaling, which is an inhibitor of glycogen synthetase kinase-3 (GSK-3), maintaining the stability of β-catenin in cytosolic. We showed BAMBI strengthened the anti-adipogenic effects of LiCl. In addition, the results indicated that BAMBI was upregulated by β-catenin. These observations illuminated that BAMBI inhibits adipogenesis by a feedback loop (BAMBI→β-catenin nuclear translocation→BAMBI), which forms with Wnt/β-catenin signaling.
      PubDate: Wed, 26 Mar 2014 07:00:00 GMT
  • A new mechanism in the binding between Homer3 EVH1 domain and inositol
           1,4,5 trisphosphate receptor suppressor domain
    • Authors: He Wen; Hyuk Nam Kwon, Sunghyouk Park
      Abstract: Biochemistry and Cell Biology, Volume 92, Issue 3, Page 163-171, June 2014. The suppressor domain of inositol 1,4,5 trisphosphate receptor (IP3R) has critical roles in regulating the calcium channel by interacting with many binding partners. The residue 49–53 (PPKKF) of the suppressor domain was suggested to be a canonical Homer EVH1 domain binding site and is also the first a part of calmodulin (CaM) binding site. As CaM-binding of the suppressor domain has been shown to involve large-scale conformational changes, we studied the binding characteristics of the Homer EVH1-suppressor domain with NMR spectroscopy and biochemical pull-down assays for mutants. Our data show that the suppressor domain employs the PPKKF motif in a similar but subtly different way compared to previously characterized interactions, and that the suppressor domain does not undergo large-scale conformational changes. Chemical shift assignments of the Homer3 EVH1 domain found that a new set of residues, located at the opposite side of the previously reported binding site, is also involved in binding, which was confirmed by mutant binding assays. Further analysis suggests that F40 in the new binding sites may have a critical role as a conformational lock-switch in Homer-target binding. The proposed mechanism is implicated in the signaling network involving calcium channels.
      PubDate: Mon, 10 Mar 2014 07:00:00 GMT
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