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Publisher: Elsevier   (Total: 3175 journals)

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Showing 2001 - 2200 of 3175 Journals sorted alphabetically
J. of the Saudi Heart Association     Open Access   (Followers: 1, SJR: 0.292, h-index: 5)
J. of the Saudi Society of Agricultural Sciences     Open Access   (Followers: 2)
J. of the Saudi Society of Dermatology & Dermatologic Surgery     Open Access   (Followers: 1)
J. of the Taiwan Institute of Chemical Engineers     Hybrid Journal   (Followers: 2, SJR: 0.736, h-index: 34)
J. of the World Federation of Orthodontists     Full-text available via subscription  
J. of Theoretical & Philosophical Psychology     Full-text available via subscription   (Followers: 2, SJR: 0.385, h-index: 16)
J. of Theoretical Biology     Hybrid Journal   (Followers: 14, SJR: 1.089, h-index: 121)
J. of Thermal Biology     Hybrid Journal   (Followers: 4, SJR: 0.491, h-index: 45)
J. of Thoracic and Cardiovascular Surgery     Hybrid Journal   (Followers: 13, SJR: 2.369, h-index: 161)
J. of Thoracic Oncology     Hybrid Journal   (Followers: 4, SJR: 2.597, h-index: 81)
J. of Tissue Viability     Full-text available via subscription   (Followers: 2, SJR: 0.542, h-index: 20)
J. of Trace Elements in Medicine and Biology     Hybrid Journal   (Followers: 1, SJR: 0.576, h-index: 49)
J. of Traditional and Complementary Medicine     Open Access   (Followers: 1, SJR: 0.486, h-index: 7)
J. of Traditional Chinese Medical Sciences     Open Access   (Followers: 1)
J. of Traditional Chinese Medicine     Open Access   (Followers: 3, SJR: 0.368, h-index: 17)
J. of Traffic and Transportation Engineering (English Edition)     Open Access   (Followers: 5)
J. of Transport & Health     Hybrid Journal   (Followers: 8, SJR: 0.463, h-index: 5)
J. of Transport Geography     Hybrid Journal   (Followers: 23, SJR: 1.734, h-index: 58)
J. of Transportation Systems Engineering and Information Technology     Full-text available via subscription   (Followers: 12, SJR: 0.255, h-index: 13)
J. of Unconventional Oil and Gas Resources     Hybrid Journal   (Followers: 2, SJR: 1.066, h-index: 6)
J. of Urban Economics     Hybrid Journal   (Followers: 15, SJR: 2.434, h-index: 74)
J. of Urban Management     Open Access  
J. of Urology     Full-text available via subscription   (Followers: 49, SJR: 2.259, h-index: 211)
J. of Vascular and Interventional Radiology     Hybrid Journal   (Followers: 10, SJR: 1.21, h-index: 104)
J. of Vascular Nursing     Hybrid Journal   (Followers: 1, SJR: 0.211, h-index: 18)
J. of Vascular Surgery     Hybrid Journal   (Followers: 27, SJR: 2.115, h-index: 154)
J. of Vascular Surgery : Venous and Lymphatic Disorders     Hybrid Journal   (Followers: 4, SJR: 0.54, h-index: 8)
J. of Vascular Surgery Cases and Innovative Techniques     Open Access   (Followers: 2)
J. of Veterinary Behavior: Clinical Applications and Research     Hybrid Journal   (Followers: 2, SJR: 0.658, h-index: 19)
J. of Veterinary Cardiology     Full-text available via subscription   (Followers: 7, SJR: 0.734, h-index: 25)
J. of Virological Methods     Hybrid Journal   (Followers: 7, SJR: 0.866, h-index: 79)
J. of Visceral Surgery     Full-text available via subscription   (Followers: 1, SJR: 0.297, h-index: 12)
J. of Visual Communication and Image Representation     Hybrid Journal   (Followers: 8, SJR: 0.785, h-index: 54)
J. of Visual Languages & Computing     Hybrid Journal   (Followers: 1, SJR: 0.411, h-index: 38)
J. of Vocational Behavior     Hybrid Journal   (Followers: 17, SJR: 1.741, h-index: 101)
J. of Voice     Hybrid Journal   (Followers: 41, SJR: 0.878, h-index: 60)
J. of Volcanology and Geothermal Research     Hybrid Journal   (Followers: 16, SJR: 1.714, h-index: 88)
J. of Water Process Engineering     Full-text available via subscription   (Followers: 4, SJR: 0.633, h-index: 6)
J. of Wind Engineering and Industrial Aerodynamics     Hybrid Journal   (Followers: 7, SJR: 1.097, h-index: 72)
J. of World Business     Hybrid Journal   (Followers: 10, SJR: 1.656, h-index: 67)
JAAD Case Reports     Open Access  
JACC : Basic to Translational Science     Open Access   (Followers: 2)
JACC : Cardiovascular Imaging     Hybrid Journal   (Followers: 11, SJR: 3.591, h-index: 71)
JACC : Cardiovascular Interventions     Hybrid Journal   (Followers: 14, SJR: 5.063, h-index: 76)
JACC : Clinical Electrophysiology     Full-text available via subscription   (Followers: 4)
JACC : Heart Failure     Full-text available via subscription   (Followers: 11, SJR: 4.318, h-index: 18)
Japan and the World Economy     Hybrid Journal   (Followers: 2, SJR: 0.477, h-index: 24)
Japanese Dental Science Review     Open Access   (SJR: 0.215, h-index: 11)
JCC Open : J. de Cas Cliniques     Open Access  
JCRS Online Case Reports     Open Access   (SJR: 0.112, h-index: 1)
Joint Bone Spine     Full-text available via subscription   (Followers: 13, SJR: 0.807, h-index: 57)
Joint Commission J. on Quality and Patient Safety     Hybrid Journal   (Followers: 33, SJR: 0.75, h-index: 59)
Jornal de Pediatria     Open Access   (Followers: 1, SJR: 0.766, h-index: 36)
Jornal de Pediatria (Versão em Português)     Full-text available via subscription  
Joule     Hybrid Journal  
JPRAS Open     Open Access  
Kaohsiung J. of Medical Sciences     Open Access   (SJR: 0.443, h-index: 24)
Karbala Intl. J. of Modern Science     Open Access   (Followers: 3)
Kasetsart J. of Social Sciences     Open Access   (Followers: 1)
Kidney Intl. Reports     Open Access   (Followers: 1)
Kidney Intl. Supplements     Partially Free   (Followers: 3, SJR: 2.976, h-index: 11)
Kinésithérapie, la Revue     Full-text available via subscription   (Followers: 1, SJR: 0.159, h-index: 3)
King Saud University J. of Dental Sciences     Open Access  
Knowledge-Based Systems     Hybrid Journal   (Followers: 5, SJR: 2.14, h-index: 63)
Komplementäre und Integrative Medizin     Full-text available via subscription  
Kontakt     Full-text available via subscription  
Krankenhaus-Hygiene - Infektionsverhütung     Full-text available via subscription   (SJR: 0.102, h-index: 4)
L'Anthropologie     Full-text available via subscription   (Followers: 7, SJR: 0.384, h-index: 23)
L'Encéphale     Full-text available via subscription   (Followers: 1, SJR: 0.313, h-index: 39)
La Presse Médicale     Full-text available via subscription   (Followers: 3, SJR: 0.246, h-index: 31)
La Revue d'Homéopathie     Full-text available via subscription   (SJR: 0.188, h-index: 2)
La Revue de Medecine Interne     Full-text available via subscription   (Followers: 3, SJR: 0.237, h-index: 30)
La Revue de Médecine Légale     Full-text available via subscription   (SJR: 0.193, h-index: 3)
La Revue Gestion et Organisation     Open Access  
La Revue Sage-Femme     Full-text available via subscription   (SJR: 0.101, h-index: 2)
Laboratory Techniques in Biochemistry and Molecular Biology     Full-text available via subscription   (Followers: 4)
Labour Economics     Hybrid Journal   (Followers: 41, SJR: 1.127, h-index: 50)
Lancet Public Health     Open Access   (Followers: 6)
Land Use Policy     Hybrid Journal   (Followers: 19, SJR: 1.438, h-index: 66)
Landscape and Urban Planning     Hybrid Journal   (Followers: 26, SJR: 1.699, h-index: 102)
Language & Communication     Hybrid Journal   (Followers: 13, SJR: 0.633, h-index: 30)
Language Sciences     Hybrid Journal   (Followers: 3, SJR: 0.377, h-index: 27)
Large Marine Ecosystems     Full-text available via subscription   (Followers: 1)
Le Pharmacien Hospitalier     Full-text available via subscription  
Le Pharmacien Hospitalier et Clinicien     Full-text available via subscription   (Followers: 1, SJR: 0.237, h-index: 6)
Le Praticien en Anesthésie Réanimation     Full-text available via subscription   (Followers: 2, SJR: 0.104, h-index: 3)
Learning and Individual Differences     Hybrid Journal   (Followers: 10, SJR: 1.057, h-index: 47)
Learning and Instruction     Hybrid Journal   (Followers: 24, SJR: 2.851, h-index: 73)
Learning and Motivation     Hybrid Journal   (Followers: 18, SJR: 0.589, h-index: 35)
Learning, Culture and Social Interaction     Hybrid Journal   (Followers: 3)
Legal Medicine     Hybrid Journal   (Followers: 354, SJR: 0.908, h-index: 32)
Les Houches Summer School Proceedings     Full-text available via subscription   (Followers: 1)
Leukemia Research     Hybrid Journal   (Followers: 8, SJR: 1.043, h-index: 70)
Leukemia Research Reports     Open Access   (Followers: 2, SJR: 0.407, h-index: 5)
Library & Information Science Research     Hybrid Journal   (Followers: 1238, SJR: 1.629, h-index: 41)
Life Sciences     Hybrid Journal   (Followers: 6, SJR: 1.056, h-index: 132)
Life Sciences in Space Research     Hybrid Journal   (Followers: 2, SJR: 0.626, h-index: 5)
Limnologica - Ecology and Management of Inland Waters     Hybrid Journal   (Followers: 4, SJR: 0.668, h-index: 32)
Linear Algebra and its Applications     Full-text available via subscription   (Followers: 14, SJR: 0.837, h-index: 65)
Lingua     Hybrid Journal   (Followers: 14, SJR: 0.768, h-index: 37)
Linguistics and Education     Hybrid Journal   (Followers: 12, SJR: 0.669, h-index: 28)
Literatura Mexicana     Open Access  
Lithos     Hybrid Journal   (Followers: 12, SJR: 2.92, h-index: 110)
Livestock Science     Hybrid Journal   (Followers: 6, SJR: 0.837, h-index: 81)
Long Range Planning     Hybrid Journal   (Followers: 12, SJR: 1.958, h-index: 69)
Lung Cancer     Hybrid Journal   (Followers: 14, SJR: 1.923, h-index: 98)
LWT - Food Science and Technology     Hybrid Journal   (Followers: 6, SJR: 1.3, h-index: 84)
Machine Intelligence and Pattern Recognition     Full-text available via subscription   (Followers: 13)
Magister : Revista de Investigación Educativa     Full-text available via subscription  
Magnetic Resonance Imaging     Hybrid Journal   (Followers: 5, SJR: 1.139, h-index: 87)
Magnetic Resonance Imaging Clinics of North America     Full-text available via subscription   (Followers: 5, SJR: 0.746, h-index: 40)
Mammalian Biology - Zeitschrift für Säugetierkunde     Hybrid Journal   (Followers: 4, SJR: 0.863, h-index: 29)
Management Accounting Research     Hybrid Journal   (Followers: 16, SJR: 1.913, h-index: 56)
Manual Therapy     Hybrid Journal   (Followers: 27, SJR: 0.863, h-index: 64)
Manufacturing Letters     Full-text available via subscription   (Followers: 1, SJR: 0.608, h-index: 5)
Manufacturing Research and Technology     Full-text available via subscription   (Followers: 2)
Marine and Petroleum Geology     Hybrid Journal   (Followers: 21, SJR: 1.372, h-index: 75)
Marine Chemistry     Hybrid Journal   (Followers: 7, SJR: 1.389, h-index: 99)
Marine Environmental Research     Hybrid Journal   (Followers: 25, SJR: 1.113, h-index: 69)
Marine Genomics     Hybrid Journal   (Followers: 1, SJR: 0.984, h-index: 17)
Marine Geology     Hybrid Journal   (Followers: 32, SJR: 1.489, h-index: 98)
Marine Micropaleontology     Hybrid Journal   (Followers: 1, SJR: 1.1, h-index: 68)
Marine Policy     Hybrid Journal   (Followers: 59, SJR: 1.567, h-index: 60)
Marine Pollution Bulletin     Hybrid Journal   (Followers: 26, SJR: 1.264, h-index: 113)
Marine Structures     Hybrid Journal   (Followers: 5, SJR: 1.746, h-index: 41)
Materials & Design     Hybrid Journal   (Followers: 42)
Materials Characterization     Hybrid Journal   (Followers: 33, SJR: 1.267, h-index: 61)
Materials Chemistry and Physics     Full-text available via subscription   (Followers: 17, SJR: 0.733, h-index: 104)
Materials Discovery     Full-text available via subscription  
Materials Letters     Hybrid Journal   (Followers: 11, SJR: 0.807, h-index: 99)
Materials Research Bulletin     Hybrid Journal   (Followers: 26, SJR: 0.753, h-index: 79)
Materials Science and Engineering: A     Hybrid Journal   (Followers: 41, SJR: 1.803, h-index: 162)
Materials Science and Engineering: B     Hybrid Journal   (Followers: 20, SJR: 0.723, h-index: 87)
Materials Science and Engineering: C     Hybrid Journal   (Followers: 17, SJR: 1.332, h-index: 80)
Materials Science and Engineering: R: Reports     Hybrid Journal   (Followers: 15, SJR: 7.616, h-index: 107)
Materials Science in Semiconductor Processing     Hybrid Journal   (Followers: 4, SJR: 0.577, h-index: 38)
Materials Science Monographs     Full-text available via subscription   (Followers: 2)
Materials Today     Open Access   (Followers: 14, SJR: 6.876, h-index: 98)
Materials Today : Proceedings     Hybrid Journal   (SJR: 0.529, h-index: 2)
Materials Today Chemistry     Hybrid Journal  
Materials Today Communications     Full-text available via subscription   (Followers: 2, SJR: 0.138, h-index: 2)
Materials Today Energy     Hybrid Journal   (Followers: 1)
Materials Today Physics     Hybrid Journal  
Mathematical and Computer Modelling     Full-text available via subscription   (Followers: 13, SJR: 0.643, h-index: 73)
Mathematical Biosciences     Hybrid Journal   (Followers: 2, SJR: 0.719, h-index: 65)
Mathematical Social Sciences     Hybrid Journal   (Followers: 1, SJR: 0.493, h-index: 27)
Mathematics and Computers in Simulation     Hybrid Journal   (Followers: 4, SJR: 0.677, h-index: 54)
Mathematics in Science and Engineering     Full-text available via subscription  
Matrix Biology     Hybrid Journal   (Followers: 2, SJR: 1.902, h-index: 93)
Matter and Radiation at Extremes     Open Access  
Maturitas     Hybrid Journal   (Followers: 11, SJR: 1.107, h-index: 78)
Measurement     Hybrid Journal   (Followers: 2, SJR: 0.721, h-index: 47)
Meat Science     Hybrid Journal   (Followers: 5, SJR: 1.963, h-index: 113)
Mechanical Systems and Signal Processing     Hybrid Journal   (Followers: 7, SJR: 1.887, h-index: 100)
Mechanics of Materials     Hybrid Journal   (Followers: 22, SJR: 1.311, h-index: 74)
Mechanics Research Communications     Hybrid Journal   (Followers: 2, SJR: 0.937, h-index: 43)
Mechanism and Machine Theory     Hybrid Journal   (Followers: 9, SJR: 1.264, h-index: 72)
Mechanisms of Ageing and Development     Hybrid Journal   (Followers: 4, SJR: 1.737, h-index: 91)
Mechanisms of Development     Hybrid Journal   (Followers: 3, SJR: 1.368, h-index: 124)
Mechatronics     Hybrid Journal   (Followers: 6, SJR: 1.019, h-index: 62)
Médecine & Droit     Full-text available via subscription   (SJR: 0.115, h-index: 5)
Médecine & Longévité     Full-text available via subscription   (Followers: 1, SJR: 0.103, h-index: 3)
Médecine des Maladies Métaboliques     Full-text available via subscription   (Followers: 1, SJR: 0.111, h-index: 6)
Médecine du Sommeil     Full-text available via subscription   (SJR: 0.107, h-index: 4)
Médecine et Maladies Infectieuses     Full-text available via subscription   (SJR: 0.605, h-index: 23)
Médecine Nucléaire     Full-text available via subscription   (Followers: 1, SJR: 0.119, h-index: 7)
Médecine Palliative : Soins de Support - Accompagnement - Éthique     Full-text available via subscription   (Followers: 2, SJR: 0.155, h-index: 8)
Medical Clinics of North America     Full-text available via subscription   (Followers: 3, SJR: 0.796, h-index: 67)
Medical Dosimetry     Hybrid Journal   (Followers: 5, SJR: 0.532, h-index: 30)
Medical Engineering & Physics     Hybrid Journal   (Followers: 9, SJR: 0.784, h-index: 76)
Medical Hypotheses     Hybrid Journal   (Followers: 6, SJR: 0.464, h-index: 65)
Medical Image Analysis     Hybrid Journal   (Followers: 11, SJR: 2.048, h-index: 89)
Medical J. Armed Forces India     Full-text available via subscription  
Medical Mycology Case Reports     Open Access   (SJR: 0.37, h-index: 5)
Medical Photonics     Hybrid Journal   (Followers: 1)
Medicina     Open Access   (Followers: 1, SJR: 0.252, h-index: 24)
Medicina Clínica     Full-text available via subscription   (Followers: 7, SJR: 0.221, h-index: 55)
Medicina Clínica (English Edition)     Hybrid Journal   (Followers: 1)
Medicina General y de Familia     Open Access  
Medicina Intensiva     Open Access   (Followers: 3, SJR: 0.334, h-index: 18)
Medicina Intensiva (English Edition)     Hybrid Journal   (Followers: 1)
Medicina Paliativa     Hybrid Journal  
Medicine     Full-text available via subscription   (Followers: 10, SJR: 0.147, h-index: 22)
Medicine - Programa de Formación Médica Continuada Acreditado     Full-text available via subscription   (Followers: 1, SJR: 0.108, h-index: 3)
Membrane Protein Transport     Full-text available via subscription   (Followers: 1)
Membrane Science and Technology     Full-text available via subscription   (Followers: 4)
Membrane Technology     Full-text available via subscription   (Followers: 5, SJR: 0.135, h-index: 15)
Mendeleev Communications     Full-text available via subscription   (SJR: 0.436, h-index: 29)
Mental Health & Prevention     Hybrid Journal   (Followers: 3, SJR: 0.262, h-index: 3)
Mental Health and Physical Activity     Hybrid Journal   (Followers: 14, SJR: 0.772, h-index: 19)
Meta Gene     Open Access   (SJR: 0.339, h-index: 4)
Metabolic Engineering     Hybrid Journal   (Followers: 14, SJR: 3.655, h-index: 75)
Metabolic Engineering Communications     Open Access   (Followers: 4, SJR: 1.215, h-index: 3)
Metabolism     Hybrid Journal   (Followers: 12, SJR: 1.978, h-index: 105)
Metal Finishing     Full-text available via subscription   (Followers: 20, SJR: 0.148, h-index: 20)
Metal Powder Report     Full-text available via subscription   (Followers: 22, SJR: 0.113, h-index: 14)
Metamaterials     Hybrid Journal   (Followers: 4, SJR: 0.344, h-index: 21)
Methods     Hybrid Journal   (Followers: 11, SJR: 2.377, h-index: 108)
Methods in Cell Biology     Full-text available via subscription   (Followers: 6, SJR: 1.15, h-index: 59)
Methods in Enzymology     Full-text available via subscription   (Followers: 12, SJR: 1.501, h-index: 141)

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Journal Cover Archives de Pédiatrie
  [SJR: 0.198]   [H-I: 32]   [0 followers]  Follow
   Full-text available via subscription Subscription journal
   ISSN (Print) 0929-693X
   Published by Elsevier Homepage  [3175 journals]
  • CD36 gene polymorphism and plasma sCD36 as the risk factor in higher
    • Authors: M.E. Rać; K. Safranow; B. Garanty-Bogacka; V. Dziedziejko; G. Kurzawski; M. Goschorska; A. Kuligowska; N. Pauli; D. Chlubek
      Pages: 177 - 181
      Abstract: Publication date: April 2018
      Source:Archives de Pédiatrie, Volume 25, Issue 3
      Author(s): M.E. Rać, K. Safranow, B. Garanty-Bogacka, V. Dziedziejko, G. Kurzawski, M. Goschorska, A. Kuligowska, N. Pauli, D. Chlubek
      Introduction The receptor CD36 has been reported to play an important role in atherogenicity. The aim of this study was to gain insight into the relationship between CD36 gene polymorphisms or the plasma concentration of sCD36 and clinical or biochemical parameters in children. Patients and methods The study groups comprised Caucasian children with and without hypercholesterolemia. The alterations in the CD36 gene were detected by DHPLC and the plasma concentrations of sCD36 were measured by ELISA. Results The data presented suggest that the IVS4-10A allele of CD36 (rs3211892) is associated with a lower risk of hypercholesterolemia. We observed a negative correlation of the sCD36 concentration with uric acid and insulin concentrations, the HOMA-IR ratio, weight, waist and hip circumference, systolic blood pressure, body mass index, waist–hip ratio and mean arterial pressure ratio, but a positive correlation with HDL cholesterol and ApoA1 concentrations. Female gender was a significant independent predictor of a higher plasma sCD36 concentration. Conclusions The data presented suggest a possible protective effect of a higher sCD36 concentration in relation to metabolic syndrome components.

      PubDate: 2018-04-18T02:13:08Z
      DOI: 10.1016/j.arcped.2018.01.008
  • Nutritional management of cow's milk allergy in children: An update
    • Authors: C. Dupont; J.-P. Chouraqui; A. Linglart; A. Bocquet; D. Darmaun; F. Feillet; M.-L. Frelut; J.-P. Girardet; R. Hankard; J.-C. Rozé; U. Simeoni; A. Briend
      Pages: 236 - 243
      Abstract: Publication date: April 2018
      Source:Archives de Pédiatrie, Volume 25, Issue 3
      Author(s): C. Dupont, J.-P. Chouraqui, A. Linglart, A. Bocquet, D. Darmaun, F. Feillet, M.-L. Frelut, J.-P. Girardet, R. Hankard, J.-C. Rozé, U. Simeoni, A. Briend
      Cow's milk is one of the most common foods responsible for allergic reactions in children. Cow's milk allergy (CMA) involves immunoglobulin E (IgE)- and non-IgE-mediated reactions, the latter being both variable and nonspecific. Guidelines thus emphasize the need for physicians to recognize the specific syndromes of CMA and to respect strict diagnostic modalities. Whatever the clinical pattern of CMA, the mainstay of treatment is the elimination from the diet of cow's milk proteins. The challenge is that both the disease and the elimination diet may result in insufficient height and weight gain and bone mineralization. If, during CMA, the mother is not able or willing to breastfeed, the child must be fed a formula adapted to CMA dietary management, during infancy and later, if the disease persists. This type of formula must be adequate in terms of allergic efficacy and nutritional safety. In older children, when CMA persists, the use of cow's milk baked or heated at a sufficient temperature, frequently tolerated by children with CMA, may help alleviate the stringency of the elimination diet. Guidance on the implementation of the elimination diet by qualified healthcare professionals is always necessary. This guidance should also include advice to ensure adequate bone growth, especially relating to calcium intake. Specific attention should be given to children presenting with several risk factors for weak bone mineral density, i.e., multiple food allergies, vitamin D deficiency, poor sun exposure, steroid use, or severe eczema. When CMA is outgrown, a prolonged elimination diet may negatively impact the quality of the diet over the long term.

      PubDate: 2018-04-18T02:13:08Z
      DOI: 10.1016/j.arcped.2018.01.007
  • Coûts de l’hypotrophie par retard de la croissance intra-utérine
           (RCIU) attribuable à la pollution atmosphérique en France
    • Authors: C. Rafenberg; I. Annesi-Maesano
      Abstract: Publication date: Available online 19 April 2018
      Source:Archives de Pédiatrie
      Author(s): C. Rafenberg, I. Annesi-Maesano
      Exposure of pregnant women to fine particulate matter<2.5μm in diameter (PM2.5) is responsible for low birthweight (LBW) and intellectual disabilities, as expressed by a lower intelligence quotient (IQ). We estimated the attributable cost due to PM2.5 of healthcare at birth and cognitive retardation of children with LBW in metropolitan France in 2012. The cost of specific care of the 8300 (range, 3100–13,300) children born every year in France with a LBW attributable to PM2.5 exposure is estimated at €25 million (range, € 9.5–39 million). Among these 8300 children, 1880 will present an intelligence quotient (IQ) lower than the average of the general population. The annual cost of the care of these intellectual deficiencies attributable to PM2.5 is estimated at €15 million and that of the mental handicap on the lifespan of the LBW children born in 2012 attributable to PM2.5 is estimated at €1.2 billion (range, €458 million to €1.9 billion). Beyond the elevated costs borne by future generations and the intellectual impoverishment of our society, it is essential to provide continued minimal monitoring of pregnant women exposed to air pollution. For the decision-makers, it is urgent to take effective measures and actions to protect the health of exposed populations.

      PubDate: 2018-04-25T03:01:45Z
      DOI: 10.1016/j.arcped.2018.03.007
  • Ductus arteriosus aneurysm: Case report and review of the literature
    • Authors: E. Xu; J.-G. Delpey; E. Finel; A. Pennanéach
      Abstract: Publication date: Available online 12 April 2018
      Source:Archives de Pédiatrie
      Author(s): E. Xu, J.-G. Delpey, E. Finel, A. Pennanéach
      We report the case of an infant boy born at 39 weeks and 5 days who presented a cleft lip and palate. During the assessment to detect associated malformations, cardiac auscultation revealed a systolic heart murmur. Echocardiography and subsequent thoracic computed tomography angiography identified an aneurysm of the ductus arteriosus. Ductus arteriosus aneurysm, a complicated form of patent ductus arteriosus, may not be as rare as once considered. A clear majority of ductus arteriosus aneurysms are asymptomatic and physiologically resolve after birth. Nevertheless, severe complications can occur, primarily during the postnatal period.

      PubDate: 2018-04-18T02:13:08Z
      DOI: 10.1016/j.arcped.2018.03.005
  • Changes in conditions at birth in France from 1995 to 2016: Results of the
           National Perinatal Surveys
    • Authors: B. Blondel; V. Pierrat; L. Foix-L’Hélias
      Abstract: Publication date: Available online 12 April 2018
      Source:Archives de Pédiatrie
      Author(s): B. Blondel, V. Pierrat, L. Foix-L’Hélias

      PubDate: 2018-04-18T02:13:08Z
      DOI: 10.1016/j.arcped.2018.03.006
  • Parenteral nutrition for preterm infants: Issues and strategy
    • Authors: D. Darmaun; A. Lapillonne; U. Simeoni; J.-C. Picaud; J.-C. Rozé; E. Saliba; A. Bocquet; J.-P. Chouraqui; C. Dupont; F. Feillet; M.-L. Frelut; J.-P. Girardet; D. Turck; A. Briend
      Abstract: Publication date: Available online 12 April 2018
      Source:Archives de Pédiatrie
      Author(s): D. Darmaun, A. Lapillonne, U. Simeoni, J.-C. Picaud, J.-C. Rozé, E. Saliba, A. Bocquet, J.-P. Chouraqui, C. Dupont, F. Feillet, M.-L. Frelut, J.-P. Girardet, D. Turck, A. Briend
      Due to transient gut immaturity, most very preterm infants receive parenteral nutrition (PN) in the first few weeks of life. Yet providing enough protein and energy to sustain optimal growth in such infants remains a challenge. Extrauterine growth restriction is frequently observed in very preterm infants at the time of discharge from hospital, and has been found to be associated with later impaired neurodevelopment. A few recent randomized trials suggest that intensified PN can improve early growth; whether or not such early PN improves long-term neurological outcome is still unclear. Several other questions regarding what is optimal PN for very preterm infants remain unanswered. Amino acid mixtures designed for infants contain large amounts of branched-chain amino acids and taurine, but there is no consensus on the need for some nonessential amino acids such as glutamine, arginine, and cysteine. Whether excess growth in the first few weeks of life, at a time when very preterm infants receive PN, has an imprinting effect, increasing the risk of metabolic or vascular disease at adulthood continues to be debated. Even though uncertainty remains regarding the long-term effect of early PN, it appears reasonable to propose intensified initial PN. The aim of the current position paper is to review the evidence supporting such a strategy with regards to the early phase of nutrition, which is mainly covered by parenteral nutrition. More randomized trials are, however, needed to further support this type of approach and to demonstrate that this strategy improves short- and long-term outcome.

      PubDate: 2018-04-18T02:13:08Z
      DOI: 10.1016/j.arcped.2018.02.005
  • Prophylaxis in case of tick bite in Provence-Alpes-Côte d’Azur
    • Authors: P. Del Giudice
      Abstract: Publication date: Available online 11 April 2018
      Source:Archives de Pédiatrie
      Author(s): P. Del Giudice

      PubDate: 2018-04-18T02:13:08Z
      DOI: 10.1016/j.arcped.2018.03.008
  • Purpura of the chin: Two consecutive cases
    • Authors: C. Cortey; C. Bréhin; I. Claudet
      Abstract: Publication date: Available online 11 April 2018
      Source:Archives de Pédiatrie
      Author(s): C. Cortey, C. Bréhin, I. Claudet
      Two healthy children, a 10-year-old boy and a 13-year-old girl, both with no previous medical history, unrelated, presented with pinpoint purpura of the chin and the upper lip. It had appeared 2 days before and extended from the chin to the lower lip. Neither had fever or recent trauma, nor had they taken any medication. Their vital parameters and physical examination were normal. Their peripheral blood cell counts and coagulation parameters were normal. A week later, upon the follow-up consultation, the purpuric lesions had disappeared and both children reported they had played the glass game.

      PubDate: 2018-04-18T02:13:08Z
      DOI: 10.1016/j.arcped.2018.02.007
  • L’Artiste en milieu hospitalier : une expérience musicale en
           hémodialyse pédiatrique
    • Authors: M. Tanquerel; F. Broux; F. Louillet; G. De Blasi
      Abstract: Publication date: Available online 11 April 2018
      Source:Archives de Pédiatrie
      Author(s): M. Tanquerel, F. Broux, F. Louillet, G. De Blasi
      Culture at the hospital is part of a policy of providing everyone access to culture. This article describes a musical intervention that provides patients and healthcare professionals a central role in creation; qualitatively assesses the benefits of these interventions for children and caregivers; evaluate the lessons learned from this ongoing experience in the pediatric hemodialysis unit of Rouen University Hospital. Ninety-minute sessions take place twice a week, with eight children aged from 18months to 19years, during dialysis. To assess the effects of artistic interventions in the unit, a qualitative methodology was chosen (observation grid). The progression of the project is evaluated to highlight what has helped the children and caregivers reach autonomy in artistic creation while respecting the time allotted, the artistic approach, and the esthetics of each participant's creation. The results indicate that this approach allows children to be actors, that the time at the hospital is relativized, and that the relationship with the healthcare professionals is less oriented towards care. A discussion follows on the place of the artist and the untapped potential of bringing patients to the creative act; the issue of esthetics, which then becomes secondary; the complementarity between musical activities and creation, and the role each actor plays in an artistic project. The hospital can provide access to culture; however, it is possible to go further and reveal patients’ creativity.

      PubDate: 2018-04-18T02:13:08Z
      DOI: 10.1016/j.arcped.2018.03.003
  • Laparoscopic adjustable gastric banding in adolescents with severe
           obesity: Psychological aspects, decision makers of surgery, and 2-year
           outcomes. A case series
    • Authors: E. Riquin; F. Schmitt; N. Bouhours-Nouet; M. Beaumesnil; M. Dinomais; J. Malka; M. Robin; R. Coutant; P. Duverger
      Abstract: Publication date: Available online 11 April 2018
      Source:Archives de Pédiatrie
      Author(s): E. Riquin, F. Schmitt, N. Bouhours-Nouet, M. Beaumesnil, M. Dinomais, J. Malka, M. Robin, R. Coutant, P. Duverger
      Background The results of medical treatment of severe obesity in the adolescent population (balanced diet and physical activity) are often unsatisfactory, and bariatric surgery is questioned. The psychological determinants for requesting bariatric surgery in these adolescents are unclear. The objective of this study was to report the psychiatric and psychological aspects as well as the determinants of the medical decision for surgery in a cohort of obese adolescents requesting bariatric surgery by laparoscopic adjustable gastric banding. Methods Thirty-five adolescents (12.3–17.7 years of age), were recruited from January 2007 to December 2012. Semistructured interviews were conducted. Results Fifty-four percent of the adolescents had a psychiatric history and 85% had psychiatric comorbidities. In adolescents undergoing surgery, excess weight loss was 46% after 1 year and 51% after 2years. For patients not receiving surgery, excess weight loss was 0.43% after 1 year (P =0.001). Compliance with medical treatment was the only significant element contributing to the decision to perform surgery. Results in terms of satisfaction and perception 1 and 2years after surgery were encouraging. Conclusion Bariatric surgery is feasible in young patients and produces good results in terms of excess weight loss. We argue that compliance with medical treatment is probably one of the most important elements for making the decision to perform bariatric surgery and in excess weight loss after surgery. We probably need to focus on the compliance of young patients and evaluate how this can be improved.

      PubDate: 2018-04-18T02:13:08Z
      DOI: 10.1016/j.arcped.2018.02.004
  • Prospective follow-up of a cohort of preterm infants<33 WG receiving
           ketamine for tracheal intubation in the delivery room: Neurological
           outcome at 1 and 2 years
    • Authors: C. Elalouf; A.-G. Le Moing; C. Fontaine; A. Leke; G. Kongolo; J. Gondry; P. Tourneux
      Abstract: Publication date: Available online 5 April 2018
      Source:Archives de Pédiatrie
      Author(s): C. Elalouf, A.-G. Le Moing, C. Fontaine, A. Leke, G. Kongolo, J. Gondry, P. Tourneux
      Objective Although ketamine analgesia is effective in reducing pain and facilitating the tracheal intubation of newborns in the delivery room, no data on the neurological effects of this treatment are available. This study compared the neurodevelopmental outcomes at 2 years of age in a cohort of preterm newborns having received ketamine prior to tracheal intubation at birth (the ketamine group) and in a control group. Methods We included newborns delivered at less than 33 weeks gestational age (WGA) having undergone tracheal intubation at birth. The Ages and Stages Questionnaire (ASQ) was completed at 1 and 2 years of age. The development quotient (DQ) was calculated from the revised Brunet-Lezine score assessed at a corrected age of 2 years. Results There were no statistically significant differences between the ketamine group (n =54 at 1 year and n =51 at 2 years) and the control group (n =16 at 1 and 2 years) in terms of the mean±standard deviation DQ at the age of 2 (98±12 vs. 103±9, respectively; P =0.17) and the ASQ score at the age of 2 (221±44 vs. 230±39, respectively; P =0.55). Discussion This prospective cohort of 51 preterm newborns having received ketamine at birth did not reveal any differences in terms of neurological development at the age of 2 (relative to a control group and the literature data). These preliminary results must be confirmed in a randomized trial with longer follow-up.

      PubDate: 2018-04-18T02:13:08Z
      DOI: 10.1016/j.arcped.2018.03.001
  • Not all screens should be used in common living spaces
    • Authors: Osika
      Abstract: Publication date: Available online 5 April 2018
      Source:Archives de Pédiatrie
      Author(s): E. Osika

      PubDate: 2018-04-18T02:13:08Z
  • Étude du fonctionnement adaptatif d’adultes présentant une déficience
           intellectuelle : rôles des apprentissages réalisés dans l’enfance,
           de l’âge et du quotient intellectuel ; étude préliminaire
           observationnelle de 16 adultes
    • Authors: A. Minguez; M. Milh
      Abstract: Publication date: Available online 16 March 2018
      Source:Archives de Pédiatrie
      Author(s): A. Minguez, M. Milh
      The objective of this study was to investigate the adaptive functioning of adults who had a slight to moderate intellectual deficiency, in regard of age and intellectual quotient (IQ). Cognitive and adaptive functioning were evaluated using the WAIS and VINELAND scales in 16 adults who accepted to participate in this study. We found a correlation between global IQ and each domain of the adaptive score, mostly communication skills. We also found that there was an age effect on socialization skills. Most skills were learned during infancy and adolescence, especially communication skills, which are highly stable at different ages and highly correlated with IQ. However, some abilities are still acquired in adulthood, mostly socialization skills, especially in persons with the lowest IQ. These data are of particular interest for people caring for disabled adults.

      PubDate: 2018-03-19T00:22:54Z
      DOI: 10.1016/j.arcped.2018.02.002
  • Troubles en mathématiques : une origine multiple ' L’exemple des
           syndromes de Turner et de l’X Fragile
    • Authors: C. Deffrennes; M. De Clercq; L. Vallée; M.-P. Lemaître
      Abstract: Publication date: Available online 14 March 2018
      Source:Archives de Pédiatrie
      Author(s): C. Deffrennes, M. De Clercq, L. Vallée, M.-P. Lemaître
      Problems in mathematics are a frequent major complaint in neuropediatric departments, for which there are two explanatory theoretical models: the hypothesis of a genetic and modular origin (with a number sense deficit) and a multidetermined origin. The purpose of this paper is to review the mathematical difficulties described in Turner syndrome and Fragile X syndrome, because a specific mathematical disorder is usually reported in these populations, supporting the existence of a number sense. Analysis of the literature reveals highly variable cognitive phenotypes in these populations, especially regarding mathematical abilities. Performance heterogeneity might be related to different factors such as the abilities needed to perform the task, the variability of definitions, the different tests used in the studies and the heterogeneity of the syndromes themselves. A number sense deficit is usually described in these syndromes, but variable cognitive impairments are also observed. The idea of a modular functioning is then debated and we argue for the necessity of a global cognitive evaluation approach.

      PubDate: 2018-03-19T00:22:54Z
      DOI: 10.1016/j.arcped.2018.01.001
  • Hypercholesterolemia in children: Why and how to screen for it'
    • Authors: J.- P. Girardet; A. Bocquet; J.P. Chouraqui; D. Darmaun; F. Feillet; M.-L. Frelut; R. Hankard; J.-C. Rozé; U. Simeoni; D. Turck; A. Briend; C. Dupont
      Abstract: Publication date: Available online 13 March 2018
      Source:Archives de Pédiatrie
      Author(s): J.- P. Girardet, A. Bocquet, J.P. Chouraqui, D. Darmaun, F. Feillet, M.-L. Frelut, R. Hankard, J.-C. Rozé, U. Simeoni, D. Turck, A. Briend, C. Dupont

      PubDate: 2018-03-19T00:22:54Z
      DOI: 10.1016/j.arcped.2018.01.005
  • Tout ce que vous devez connaître sur le méthylphénidate (sans oser le
    • Authors: L. Zimmer; P. Fourneret
      Abstract: Publication date: Available online 12 March 2018
      Source:Archives de Pédiatrie
      Author(s): L. Zimmer, P. Fourneret
      Methylphenidate (MPH) remains the only accessible psychostimulant used in France in the attention and behavior disturbances of attention deficit disorder with or without hyperactivity (ADHD). Its prescription has been extended during the past decade to other neurodevelopmental disorders in children and adolescents, also associated with a deficit of attentional resources or, more broadly, fragility of executive functions. Despite its efficiency, validated by more than 400 randomized controlled and double-blind studies, and the good tolerance of MPH in these indications, this treatment remains limited in France because of many fears and other prejudices on the part of medical practitioners and/or families. This article, resulting from the complementary viewpoints of a psychiatrist and a neuropharmacologist, is not intended to advocate MPH but to present, in a concise and nuanced manner, the approved scientific data justifying and framing this prescription.

      PubDate: 2018-03-19T00:22:54Z
      DOI: 10.1016/j.arcped.2018.01.002
  • Acute hemorrhagic edema of infancy associated with Coxsackie virus
    • Authors: A. Ferrarini; G.P. Milani; M.G. Bianchetti; S.A.G. Lava
      Abstract: Publication date: Available online 12 March 2018
      Source:Archives de Pédiatrie
      Author(s): A. Ferrarini, G.P. Milani, M.G. Bianchetti, S.A.G. Lava

      PubDate: 2018-03-19T00:22:54Z
      DOI: 10.1016/j.arcped.2018.01.006
  • Préparation et administration des médicaments dans les services de
           pédiatrie. Évaluation des pratiques des soignants
    • Authors: S. Ménétré; M. Weber; M. Socha; S. Le Tacon; I. May; C. Schweitzer; B. Demoré
      Abstract: Publication date: Available online 2 February 2018
      Source:Archives de Pédiatrie
      Author(s): S. Ménétré, M. Weber, M. Socha, S. Le Tacon, I. May, C. Schweitzer, B. Demoré
      In hospitals, the nursing staff is often confronted with the problem of the preparation and administration of drugs for their pediatric patients because of the lack of indication, pediatric dosage, and appropriate galenic form. The goal of this study was to give an overview of the nurses’ preparation habits in pediatric units and highlight their daily problems. This single-center prospective study was conducted through an observation of the nursing staff during the drug preparation process in medicine, surgery and intensive care units. We included 91 patients (55 boys and 36 girls), with an average age of 6.3 years (youngest child, 10 days old; oldest child, 18 years old). We observed a mean 2.16 drug preparations per patient [1–5]. We collected 197 observation reports regarding 66 injectable drugs and 131 oral drugs (71 liquid forms and 60 solid forms). The majority of these reports concerned central nervous system drugs (63/197), metabolism and digestive system drugs (50/197), and anti-infective drugs (46/197). The study highlights the nurses’ difficulties: modification of the solid galenic forms, lack of knowledge on oral liquid form preservation or reconstitution methods, withdrawal of small volumes, and vague and noncompliant labeling. This study led to the creation of a specific working group for pediatrics. This multidisciplinary team meets on a regular basis to work toward improving the current habits to both simplify and secure drug administration to hospitalized children.

      PubDate: 2018-02-04T21:46:52Z
      DOI: 10.1016/j.arcped.2017.12.002
  • Hemodynamic support of a 15-year-old waiting for a heart transplant: Is
           there a role for levosimendan in pediatric heart failure'
    • Authors: I. Goyer; D. Brossier; B. Toledano
      Abstract: Publication date: Available online 1 February 2018
      Source:Archives de Pédiatrie
      Author(s): I. Goyer, D. Brossier, B. Toledano
      Decompensated heart failure in children requires rapid and aggressive support. In refractory cases, invasive supportive care is essential to ensure cardiac output. This results in lengthy pediatric intensive care unit (PICU) stays, secondary morbidity, and high cost. Levosimendan may help palliate the pitfalls encountered with the usual treatment. It has been shown to improve hemodynamics and decrease morbidity and mortality from heart failure in adult trials and pediatric cohorts. We report the case of a 15-year-old boy with dilated cardiomyopathy and refractory ventricular dysfunction who was weaned from continuous inotropes and discharged from the PICU with levosimendan while waiting for heart transplantation.

      PubDate: 2018-02-04T21:46:52Z
      DOI: 10.1016/j.arcped.2017.12.003
  • Sudden unexpected infant death: Time for integrative national registries
    • Authors: K. Levieux; H. Patural; I. Harrewijn; E. Briand Huchet; B. Kugener; O. Pidoux; S. de Visme; C. Adjaoud; C. Gras Le Guen; M. Hanf
      Abstract: Publication date: Available online 1 February 2018
      Source:Archives de Pédiatrie
      Author(s): K. Levieux, H. Patural, I. Harrewijn, E. Briand Huchet, B. Kugener, O. Pidoux, S. de Visme, C. Adjaoud, C. Gras Le Guen, M. Hanf

      PubDate: 2018-02-04T21:46:52Z
      DOI: 10.1016/j.arcped.2017.12.008
  • HIV infection in children as an example of chronic disease management in
           French-speaking Africa
    • Authors: M. Sylla; C.T. Tall; S. Blanche
      Abstract: Publication date: Available online 1 February 2018
      Source:Archives de Pédiatrie
      Author(s): M. Sylla, C.T. Tall, S. Blanche

      PubDate: 2018-02-04T21:46:52Z
      DOI: 10.1016/j.arcped.2017.12.007
  • Exploration d’une avance staturale chez l’enfant : conduite à tenir
           pratique, principales étiologies à évoquer
    • Authors: J. Vergier; E. Marquant; T. Busa; R. Reynaud
      Abstract: Publication date: Available online 1 February 2018
      Source:Archives de Pédiatrie
      Author(s): J. Vergier, E. Marquant, T. Busa, R. Reynaud
      Tall stature is not a common motive for medical consultation, even though by definition 2.5 % of children in the general population are concerned. It is usually defined as height greater than+2 standard deviations (SD) using the appropriate growth chart for age and gender, or a difference greater than +2 SD between actual height and target height. With a patient presenting tall stature, the physician has to determine whether it is a benign feature or a disease. Indeed, making the diagnosis is essential for hormonal disease or genetic overgrowth syndromes. The past medical history including parents’ height, prenatal and birth data, physical examination along with anthropometry (height, weight, head circumference, body mass index), and growth chart evaluation with the detailed growth pattern are generally sufficient to make the diagnosis such as familial tall stature, obesity, or early puberty. Bone age estimation may be helpful for some specific etiologies and is also necessary to help predict final adult height. After exclusion of common causes, further investigation is required. Sudden growth acceleration often reveals endocrine pathology such as early puberty, hyperthyroidism, or acrogigantism. Tall stature accompanied by dysmorphic features, congenital malformations, developmental delay, or a family medical history may be related to genetic disorders such as Marfan, Sotos, or Wiedemann-Beckwith syndromes. We relate here the most frequent etiologies of overgrowth syndromes.

      PubDate: 2018-02-04T21:46:52Z
      DOI: 10.1016/j.arcped.2017.12.010
  • Bowel obstruction due to ingestion of a water-absorbing bead
    • Authors: M. Fuger; C. Desmoulins; N. Khen Dunlop; F. Gobbo; P. Blakime; G. Chéron
      Abstract: Publication date: Available online 1 February 2018
      Source:Archives de Pédiatrie
      Author(s): M. Fuger, C. Desmoulins, N. Khen Dunlop, F. Gobbo, P. Blakime, G. Chéron
      Foreign body ingestion is a common pediatric complaint. Most foreign bodies pass spontaneously through the gastrointestinal tract, but bowel obstruction is a rare complication that can occur. We report a case of a 14-month-old infant with complete bowel obstruction due to ingestion of a polymer bead used for botanical arrangements. A laparotomy was performed to remove the object, resolving the symptoms. Polymer beads are brightly coloured and are of a size that is easy to swallow by very young children, increasing the risk of accidental ingestion. They increase in size over a short period of time during their passage through the gastrointestinal tract, causing significant morbidity.

      PubDate: 2018-02-04T21:46:52Z
      DOI: 10.1016/j.arcped.2017.12.004
  • Postdiarrheal hemolytic and uremic syndrome with severe multiorgan
           involvement and associated early risk factors
    • Authors: M. Oualha; S. Pierrepont; P. Krug; C. Gitiaux; P. Hubert; F. Lesage; R. Salomon
      Abstract: Publication date: Available online 1 February 2018
      Source:Archives de Pédiatrie
      Author(s): M. Oualha, S. Pierrepont, P. Krug, C. Gitiaux, P. Hubert, F. Lesage, R. Salomon
      Aim Identifying early clinical and biological factors associated with severe forms of postdiarrheal hemolytic uremic syndrome (D+HUS) that may help practitioners determine appropriate treatment. Methods This retrospective study was conducted in 49 children with D+HUS between 2001 and 2011. Severe forms were defined as occurrence of one of the following conditions: death, major neurological involvement, cardiovascular involvement, and/or the presence of sequelae (neurological, cardiovascular, pancreatic, or renal). Results During the acute phase, 35 children exhibited at least one type of extrarenal involvement including 13 severe forms with a median delayed occurrence after admission of 4.5 days (range: 1–8) for comatose children and 5 days (range: 2–6) for cardiovascular involvement; 32 children required dialysis and three died. In multivariate analysis, (i) major neurological involvement (n =13), (ii) dialysis (n =32), and (iii) sequelae (n =12) were associated with (i) fever during the prodromal phase requiring dialysis at admission, (ii) C-reactive protein level (CRP) >22mg/L at admission, and (iii) major neurological involvement and a white blood cell count (WBC)>20×103/mm3 during the acute stage, respectively. Conclusions D+HUS is a multiorgan disease with a delayed occurrence of life-threatening extrarenal organ involvement. Severe forms appear to be associated with early biological and clinical inflammatory parameters.

      PubDate: 2018-02-04T21:46:52Z
      DOI: 10.1016/j.arcped.2017.12.005
  • Peau et fièvres récurrentes auto-inflammatoires
    • Authors: A. Escudier; F.-X. Mauvais; P. Bastard; C. Boussard; A. Jaoui; V. Koskas; E. Lecoq; A. Michel; M.-C. Orcel; P.-E. Truelle; D. Wohrer; M. Piram
      Abstract: Publication date: Available online 1 February 2018
      Source:Archives de Pédiatrie
      Author(s): A. Escudier, F.-X. Mauvais, P. Bastard, C. Boussard, A. Jaoui, V. Koskas, E. Lecoq, A. Michel, M.-C. Orcel, P.-E. Truelle, D. Wohrer, M. Piram
      Auto-inflammatory diseases are characterized by unexplained and recurrent attacks of systemic inflammation often involving the skin, joints, or serosal membranes. They are due to a dysfunction or dysregulation of the innate immunity, which is the first line of defense against pathogens. Early recognition of these diseases by the clinician, especially by pediatricians encountering such pathologies in pediatric patients, is primordial to avoid complications. Skin manifestations, common in most auto-inflammatory diseases, are helpful for prompt diagnosis. After a brief physiopathological review, we will describe auto-inflammatory recurrent fevers by their main dermatological presentations: urticarial lesions, neutrophilic dermatoses, panniculitis, other maculopapular eruptions, dyskeratosis, skin vasculitis, and oral aphthous. We finally suggest a decision tree to help clinicians better target genetic exams in patients with recurrent fevers and dermatological manifestations.

      PubDate: 2018-02-04T21:46:52Z
      DOI: 10.1016/j.arcped.2017.12.001
  • Palivizumab administration in preterm infants in France: EPIPAGE-2 cohort
    • Authors: H. Torchin; J. Rousseau; L. Marchand-Martin; P. Truffert; P.-H. Jarreau; P.-Y. Ancel
      Abstract: Publication date: Available online 1 February 2018
      Source:Archives de Pédiatrie
      Author(s): H. Torchin, J. Rousseau, L. Marchand-Martin, P. Truffert, P.-H. Jarreau, P.-Y. Ancel
      Background Several countries, including France, have restricted the indications for monoclonal antibodies directed against respiratory syncytial virus (RSV) compared to the marketing authorization (MA). No new data concerning use of palivizumab on a national scale have been published since the 2007 update of the national guidelines. Objectives To describe palivizumab administration for RSV prophylaxis during the first RSV season in infants born prematurely in France in 2011. Methods Infants from the national population-based cohort EPIPAGE-2 born at≤34 weeks’ gestation, discharged home before 31 March 2012 and followed-up at 1year were included. The RSV season ran from 1 October 2011 to 31 March 2012. Prophylaxis was deemed “initiated” if the infant had received at least one dose of palivizumab during this period and “complete” if it had received at least five doses or as many doses as the number of exposed months. The reference documents were the MA and French Transparency Committee guidelines (TC). Results Prophylaxis was indicated in 3586 of 3608 infants (99.7%) according to the MA and 1315 of 3608 (16.7%) according to the TC. A total of 1906 infants (26.6%) received at least one dose of palivizumab. The overall rate of conformity with TC indications was 85%, but was lower for infants born at 27–32 weeks’ gestation. The rate of complete prophylaxis was 77.2%. The factors associated with prophylaxis initiation were low gestational age, low birthweight, high maternal educational level, type of neonatal unit, and date at discharge. Factors associated with complete prophylaxis were respiratory impairment, high educational level, and characteristics related to living conditions (absence of siblings at home, type of childcare). Conclusions Palivizumab administration in France generally conformed with TC guidelines, but could be further improved for infants born at 27–32 weeks’ gestation without bronchopulmonary dysplasia.

      PubDate: 2018-02-04T21:46:52Z
      DOI: 10.1016/j.arcped.2017.12.009
  • 2018, a turning point for the Archives de Pédiatrie
    • Authors: Chabrol
      Abstract: Publication date: January 2018
      Source:Archives de Pédiatrie, Volume 25, Issue 1
      Author(s): B. Chabrol

      PubDate: 2018-01-25T21:14:35Z
  • La maladie thrombo-embolique veineuse en oncologie pédiatrique
    • Authors: A. Theron; C. Biron-Andreani; S. Haouy; L. Saumet; M. Saguintah; E. Jeziorski; N. Sirvent
      Abstract: Publication date: Available online 8 January 2018
      Source:Archives de Pédiatrie
      Author(s): A. Theron, C. Biron-Andreani, S. Haouy, L. Saumet, M. Saguintah, E. Jeziorski, N. Sirvent
      The survival rate of children with cancer is now close to 80 %, as a result of continuous improvement in diagnostic and treatment procedures. Prevention and treatment of treatment-associated complications is now a major challenge. Thromboembolic venous disease, due to multifactorial pathogenesis, is a frequent complication (up to 40 % asymptomatic thrombosis in children with cancer), responsible for significant morbidity. Predominantly in children with acute lymphoblastic leukemia, lymphoma, or sarcoma, thromboembolic disease justifies primary prophylaxis in certain populations at risk, whether genetic or environmental. The curative treatment, well codified, is based on the administration of low-molecular-weight heparin. In the absence of robust pediatric prospective studies, this article proposes a concise decision tree summarizing the preventive and curative strategy.

      PubDate: 2018-01-09T19:12:23Z
      DOI: 10.1016/j.arcped.2017.10.029
  • Amélioration de la santé orale des enfants avec autisme : les outils à
           notre disposition
    • Authors: A. Rouches; G. Lefer; S. Dajean-Trutaud; S. Lopez-Cazaux
      Abstract: Publication date: Available online 18 December 2017
      Source:Archives de Pédiatrie
      Author(s): A. Rouches, G. Lefer, S. Dajean-Trutaud, S. Lopez-Cazaux
      Autism spectrum disorder (ASD) is a life-long heterogeneous psychiatric disorder, characterized by impaired social interaction and communication, and the presence of repetitive and stereotyped behaviors as well as restricted interests. These features have an impact on the oral health of these individuals: high risk of dental caries, poorer periodontal status, and bruxism are often described. Children with ASD often provide limited collaboration with medical procedures, particularly those considered invasive such as dental care. Children with ASD are prone to agitation, self-injury, and emotional dysregulation; they can also present hypersensitivity to sensory input. These features make it difficult for professionals to examine and treat children with ASD; they interfere with dental care and constitute a barrier to it. Most of them are treated under general anesthesia or sedation. Therefore, children with ASD present a challenge for the dental community. Adapted and specific strategies are required to allow individuals with ASD to go beyond the barriers of dental care. Different tools and techniques of evidence-based practice can be considered: visual pedagogy, behavioral approaches, and numeric devices can be used. Pediatricians have a key role in the oral care of children with autism. The aim of this article is to present the oral health associated with ASD, to set out the possible ways to improve oral health, to enable the practitioner to detect problems, to raise awareness, and to help patients and their families in their care pathway.

      PubDate: 2017-12-23T18:27:11Z
      DOI: 10.1016/j.arcped.2017.11.013
  • Le vécu par le pédiatre de l’annonce d’une « mauvaise nouvelle »
           à l’enfant et à l’adolescent
    • Authors: Crosnier-Schoedel Carbajal; Leverger
      Abstract: Publication date: Available online 16 December 2017
      Source:Archives de Pédiatrie
      Author(s): C. Crosnier-Schoedel, N. Trocmé, R. Carbajal, G. Leverger
      Les études portant sur le vécu du pédiatre de l’annonce d’une mauvaise nouvelle à l’enfant et à l’adolescent sont quasi inexistantes. Cette annonce qui est pourtant le socle de toute prise en charge médicale est d’autant plus complexe qu’elle est plurielle, devant nécessairement passer par l’annonce faite aux parents. Nous avons proposé à 20 pédiatres hospitaliers un questionnaire de 30 questions sur le vécu de leur propre annonce d’une « Mauvaise Nouvelle » à un enfant ou un adolescent. Les obstacles auxquels ils se confrontent, malgré leur âge et le temps respectif de leur exercice de la médecine, sont multiples et sont dus à différents facteurs provenant autant des enfants, des adolescents, et de leurs familles que d’eux-mêmes. Les difficultés répertoriées par les pédiatres concernaient surtout, la notion temporelle de l’annonce, la place et le choix des mots utilisés pour la faire, et la mauvaise compréhension des enfants et de leurs familles qu’elle soit d’origine intellectuelle, culturelle ou psychique. Ensuite, ils questionnent leurs propres capacités à le faire, parfois dans l’incertitude que les choses aient été réellement comprises. Ils expriment le fait qu’eux-mêmes sont éprouvés psychiquement. Ils développent et mettent en place des stratégies pour défier l’instabilité émotionnelle que provoque l’annonce de cette « Mauvaise Nouvelle » chez la plupart d’entre eux. Pourtant, beaucoup se sentent démunis et fragilisés, jusqu’à parler d’un profond sentiment de solitude et de culpabilité. Few studies are available on pediatricians’ experience with announcing bad news. Announcing bad news is an important component of medical practice and is even more complex in pediatrics because parents must be associated. We had 20 hospital pediatricians complete a questionnaire containing 30 questions about their own experience announcing bad news to a child or a teenager. In spite of their experience and the time they have spent practicing medicine, there are many limitations stemming from different factors concerning children, teenagers, their families, and themselves. The difficulties encountered by pediatricians are mainly related to the timing of the announcement, the location, the choice of the words used, and the poor understanding of children and families, due to intellectual, cultural, or psychological limitations. Pediatricians question their own capacity to make such an announcement, wondering if the information has actually been well understood. They indicate that they are themselves affected. Most of them develop and implement strategies to refute the emotional instability caused by the announcement of bad news. Yet many of them feel weak, even talking about a deep sense of loneliness and guilt.

      PubDate: 2017-12-23T18:27:11Z
  • Staphylococcal scalded skin syndrome: An uncommon symptomatology revealing
           an immune deficiency
    • Authors: H. Ajmi; N. Jemmali; S. Mabrouk; S. Hassayoun; M. Ben-Ali; M.-R. Barbouche; M. Mokni; S. Abroug
      Abstract: Publication date: Available online 14 December 2017
      Source:Archives de Pédiatrie
      Author(s): H. Ajmi, N. Jemmali, S. Mabrouk, S. Hassayoun, M. Ben-Ali, M.-R. Barbouche, M. Mokni, S. Abroug
      Primary immune deficiencies associated with hyper-IgE syndrome are rare diseases with clinical features dominated by recurring cutaneous and visceral bacterial infections, particularly infections due to Staphylococcus species. Most of these infections are associated with milder inflammation compared to normal. We report a primary immune deficiency associated with a hyper-IgE syndrome revealed by a staphylococcal scalded skin syndrome in a 5-year-old girl. The patient presented with a severe staphylococcal infection with extensive skin lesions and disseminated intravascular coagulation. She received intravenous fluids to compensate for fluid losses and anti-staphylococcal antibiotics. Coagulopathy was also corrected. However, the progression was rapidly fatal.

      PubDate: 2017-12-23T18:27:11Z
      DOI: 10.1016/j.arcped.2017.11.008
  • Impact of obesity on biomarkers of iron and vitamin D status in children
           and adolescents: The risk of misinterpretation
    • Authors: M.-L. Frelut; J.-P. Girardet; A. Bocquet; A. Briend; J.-P. Chouraqui; D. Darmaun; C. Dupont; F. Feillet; R. Hankard; J.-C. Rozé; U. Simeoni
      Abstract: Publication date: Available online 14 December 2017
      Source:Archives de Pédiatrie
      Author(s): M.-L. Frelut, J.-P. Girardet, A. Bocquet, A. Briend, J.-P. Chouraqui, D. Darmaun, C. Dupont, F. Feillet, R. Hankard, J.-C. Rozé, U. Simeoni

      PubDate: 2017-12-23T18:27:11Z
      DOI: 10.1016/j.arcped.2017.11.011
  • Spontaneous pneumothorax: Diagnosis may be a click away
    • Authors: S. Cabasson; M.Q. Do; A. Giraudon; T. Mansir
      Abstract: Publication date: Available online 13 December 2017
      Source:Archives de Pédiatrie
      Author(s): S. Cabasson, M.Q. Do, A. Giraudon, T. Mansir
      We report the case of a 14-year-old boy presenting to our unit because of a spontaneous left pneumothorax. Over the 3 preceding weeks, he described a rhythmic precordial click and the sensation of bubbles floating inside his chest. This noise, audible to the patient and his family without a medical device, proved to be the Hamman sign, a rare although typical sound formerly related to pneumomediastinum that can be exceptionally encountered in isolated left pneumothorax. Its pathophysiology remains unclear. Small pockets of air close to the heart may be pushed inside pleura and amplified by the chest wall, hence provoking a recurrent rhythmic sound. A small left pneumothorax must be suspected whenever the Hamman sign is elicited in the absence of pneumomediastinum. Chest tomography must be precociously considered if plain x-rays are not contributive.

      PubDate: 2017-12-23T18:27:11Z
      DOI: 10.1016/j.arcped.2017.11.007
  • Évaluation des connaissances et pratiques sur le dépistage de
           l’hypercholestérolémie familiale hétérozygote chez l’enfant
    • Authors: A. Jeangeorges; A. Rubio
      Abstract: Publication date: Available online 13 December 2017
      Source:Archives de Pédiatrie
      Author(s): A. Jeangeorges, A. Rubio
      Introduction Dominant heterozygous familial hypercholesterolemia (FH) is frequent (prevalence, 1/500 to 1/250) and leads to severe and premature cardiovascular complications. It is easily detected, and its treatment is effective. However, recommendations for screening are not followed worldwide. Objectives The aim of this study was to evaluate the knowledge and practices of doctors in the Isère department, France, regarding screening and treatment of FH in children. Methods A questionnaire was distributed by email or during training sessions to general practitioners, doctors working in Infant and Mother Protection (IMP) services, and pediatricians in private practice in Isère. Results Fifty-nine doctors completed the questionnaire (overall response rate, 61%). Respondents were general practitioners (36%), IMP doctors (36%), and pediatricians in private practice (28%). Generalized screening for all children was done by only 8% of the respondents, while cascade screening, in case of familial cardiovascular medical history, was done by only 36%, of which 5% were general practitioners while 53% were doctors with a clinical practice focused on children. The most recent French recommendations by the Société française de pédiatrie and the Nouvelle Société française d’athérosclérose, which were published in 2010, had been read by only nine doctors (15%). Having read them led to a better policy of generalized screening, either generalized to all children (OR=12.0 [2.3–64.0], P =0.004) or in cascade (OR=22.8 [4.2–123.2], P <0.001). Discussion The number of questionnaires collected was small, with possible selection and declaration bias, but the different types of pediatric practice were equally represented. Conclusion Screening of FH in children is not very well organized and recommendations are not followed by doctors in Isère, France. Children with FH are probably underdiagnosed and undertreated.

      PubDate: 2017-12-23T18:27:11Z
      DOI: 10.1016/j.arcped.2017.11.004
  • Children and screens: A survey by French pediatricians
    • Authors: R. Assathiany; E. Guery; F.M. Caron; J. Cheymol; G. Picherot; P. Foucaud; N. Gelbert
      Abstract: Publication date: Available online 12 December 2017
      Source:Archives de Pédiatrie
      Author(s): R. Assathiany, E. Guery, F.M. Caron, J. Cheymol, G. Picherot, P. Foucaud, N. Gelbert
      Introduction Screens are increasingly prevalent within families. The excessive use of screens by children has negative consequences. To measure the use of screens, we undertook an investigation among children being followed by pediatricians. Methods An invitation to participate was sent electronically to 1460 private practice pediatricians. They were asked to complete the questionnaire on screen use by children under 12 years of age during a consultation, according to statements made by parents. Results One hundred and forty-four pediatricians submitted completed questionnaires involving 428 children. Among the 197 children under 3 years of age, 92 had played with an interactive screen for a median duration of 30min during the preceding week; 29% of the children were alone at the time. One hundred and thirty-nine children had watched television for a median weekly duration of 75min. Of the 231 children 3–11 years of age, 108 had played with an interactive screen for a median time of 30min the day before the consultation, and 50% of them were alone at the time. One hundred and seventy-two children watched television for a median daily duration of 45min. There was a correlation between these children's screen time and their mother's (r =0.36). The television was on during meals and continuously in 35% and 21% of the families, respectively. Conclusions Children start looking at screens early, too often watching unsuitable programs, and too often without a parent's present. Regardless of the child's age, pediatricians must ask parents how much time their children are viewing screens, advise them accordingly, and warn them of the consequences of excessive use.

      PubDate: 2017-12-13T06:24:53Z
      DOI: 10.1016/j.arcped.2017.11.001
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