http://www.journaltocs.hw.ac.uk/api/articles/dorothy%20bishop JournalTOCs API JOURNALTOCS API PROJECT 2 http://www.sciencedirect.com/science?_ob=GatewayURL&_origin=IRSSCONTENT&_method=citationSearch&_piikey=S0093934X11001805&_version=1&md5=1a3a3987d4c15891be678de8ed9a6daf Publication year: 2011<br> Source: Brain and Language, Available online 30 November 2011<br> Nicholas A. Badcock, Dorothy V.M. Bishop, Mervyn J. Hardiman, Johanna G. Barry, Kate E. Watkins<br> We assessed the relationship between brain structure and function in 10 individuals with specific language impairment (SLI), compared to six unaffected siblings, and 16 unrelated control participants with typical language. Voxel-based morphometry indicated that grey matter in the SLI group, relative to controls, was increased in the left inferior frontal cortex and decreased in the right caudate nucleus and superior temporal cortex bilaterally. The unaffected siblings also showed reduced grey matter in the caudate nucleus relative to controls. In an auditory covert naming task, the SLI group showed reduced activation in the left inferior frontal cortex, right putamen, and in the superior temporal cortex bilaterally. Despite spatially coincident structural and functional abnormalities in frontal and temporal areas, the relationships between structure and function in these regions were different. These findings suggest multiple structural and functional abnormalities in SLI that are differently associated with receptive and expressive language processing.<br> <br> <br> Graphical abstract<br> <br> <br> <br> Highlights► Compared brain structure and function in SLI, unaffected siblings, and typical peers. ► More grey matter in SLI in the left inferior frontal cortex. ► Less grey matter in SLI in the right caudate nucleus and superior temporal cortex bilaterally. ► Functional activation was examined with an auditory covert naming task. ► Functionally, SLI had reduced activation of the left inferior frontal cortex and the superior temporal cortex bilaterally.<br> <br> http://www.sciencedirect.com/science?_ob=GatewayURL&_origin=IRSSCONTENT&_method=citationSearch&_piikey=S0093934X11001805&_version=1&md5=1a3a3987d4c15891be678de8ed9a6daf SOCIAL SCIENCES: COMPREHENSIVE WORKS 2011-12-02T02:56:56Z Brain and Language, Vol. , No. (2011) pp. - Elsevier Brain and Language 2011-12-02T02:56:56Z Co-localisation of abnormal brain structure and function in specific language impairment

Brain and Language, Vol. , No. (2011) pp. -
Publication year: 2011 Source: Brain and Language, Available online 30 November 2011 Nicholas A. Badcock, Dorothy V.M. Bishop, Mervyn J. Hardiman, Johanna G. Barry, Kate E. Watkins We assessed the relationship between brain structure and function in 10 individuals with specific language impairment (SLI), compared to six unaffected siblings, and 16 unrelated control participants with typical language. Voxel-based morphometry indicated that grey matter in the SLI group, relative to controls, was increased in the left inferior frontal cortex and decreased in the right caudate nucleus and superior temporal cortex bilaterally. The unaffected siblings also showed reduced grey matter in the caudate nucleus relative to controls. In an auditory covert naming task, the SLI group showed reduced activation in the left inferior frontal cortex, right putamen, and in the superior temporal cortex bilaterally. Despite spatially coincident structural and functional abnormalities in frontal and temporal areas, the relationships between structure and function in these regions were different. These findings suggest multiple structural and functional abnormalities in SLI that are differently associated with receptive and expressive language processing. Graphical abstract Highlights► Compared brain structure and function in SLI, unaffected siblings, and typical peers. ► More grey matter in SLI in the left inferior frontal cortex. ► Less grey matter in SLI in the right caudate nucleus and superior temporal cortex bilaterally. ► Functional activation was examined with an auditory covert naming task. ► Functionally, SLI had reduced activation of the left inferior frontal cortex and the superior temporal cortex bilaterally.

]]> http://www.sciencedirect.com/science?_ob=GatewayURL&_origin=IRSSCONTENT&_method=citationSearch&_piikey=S0028393212000413&_version=1&md5=77cf2b59ae7987c6d424d4ecfe970963 Publication year: 2012<br> Source: Neuropsychologia, Available online 21 January 2012<br> Richard E Rosch, Dorothy VM Bishop, Nicholas A Badcock<br> Historically, most theoretical accounts of hemispheric specialisation have proposed a single underlying factor that leads to left hemisphere language and right hemisphere visuospatial processing in the majority of people. More recently empirical evidence has started to challenge this view, suggesting lateralisation of language and visuospatial attention are independent. However, so far studies did not control for a possible confound, task difficulty. For this study, 20 healthy right-handed volunteers underwent functional laterality assessment using functional transcranial Doppler ultrasound (fTCD). We assessed laterality using both a word generation task and a novel variation of the visuospatial landmark task that can be adjusted along two dimensions of difficulty (temporal and spatial). The visuospatial laterality measures were highly intercorrelated and unaffected by task difficulty. Furthermore, there was no correlation between visuospatial and verbal lateralisation within individuals–neither qualitatively (in direction of lateralisation), nor quantitatively (in laterality index size). These results substantiate a growing body of evidence suggesting multiple independent biases leading to the hemispheric lateralisation of different cognitive domains, thus further questioning previously accepted models of laterality development and evolution.<br> <br> <br> Graphical abstract.<br> <br> <br> Highlights► fTCD gives a reliable index of cerebral lateralisation for visuospatial attention ► Task difficulty has no effect on the laterality index in the visuospatial paradigm ► Visuospatial and language lateralisation are not correlated within subjects ► The results challenge single-factor theories of hemispheric specialisation<br> <br> http://www.sciencedirect.com/science?_ob=GatewayURL&_origin=IRSSCONTENT&_method=citationSearch&_piikey=S0028393212000413&_version=1&md5=77cf2b59ae7987c6d424d4ecfe970963 PSYCHOLOGY 2012-01-22T02:45:09Z Neuropsychologia, Vol. , No. (2012) pp. - Elsevier Neuropsychologia 2012-01-22T02:45:09Z Lateralised visual attention is unrelated to language lateralisation, and not influenced by task difficulty - a functional transcranial Doppler study

Neuropsychologia, Vol. , No. (2012) pp. -
Publication year: 2012 Source: Neuropsychologia, Available online 21 January 2012 Richard E Rosch, Dorothy VM Bishop, Nicholas A Badcock Historically, most theoretical accounts of hemispheric specialisation have proposed a single underlying factor that leads to left hemisphere language and right hemisphere visuospatial processing in the majority of people. More recently empirical evidence has started to challenge this view, suggesting lateralisation of language and visuospatial attention are independent. However, so far studies did not control for a possible confound, task difficulty. For this study, 20 healthy right-handed volunteers underwent functional laterality assessment using functional transcranial Doppler ultrasound (fTCD). We assessed laterality using both a word generation task and a novel variation of the visuospatial landmark task that can be adjusted along two dimensions of difficulty (temporal and spatial). The visuospatial laterality measures were highly intercorrelated and unaffected by task difficulty. Furthermore, there was no correlation between visuospatial and verbal lateralisation within individuals–neither qualitatively (in direction of lateralisation), nor quantitatively (in laterality index size). These results substantiate a growing body of evidence suggesting multiple independent biases leading to the hemispheric lateralisation of different cognitive domains, thus further questioning previously accepted models of laterality development and evolution. Graphical abstract. Highlights► fTCD gives a reliable index of cerebral lateralisation for visuospatial attention ► Task difficulty has no effect on the laterality index in the visuospatial paradigm ► Visuospatial and language lateralisation are not correlated within subjects ► The results challenge single-factor theories of hemispheric specialisation

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